nSTRIDE® APS Therapy

A Natural, Non-Surgical Approach to Osteoarthritis Relief

Living with osteoarthritis can be frustrating — not just because of the pain, but because it limits how you move, how you live, and how you feel day-to-day. If you’re not ready for joint replacement surgery but want more than temporary relief, nSTRIDE® APS may offer a powerful, regenerative alternative.

At Sozo Clinic, we offer nSTRIDE as a cutting-edge, single-injection therapy designed to reduce pain, improve mobility, and slow down the progression of osteoarthritis — all using healing proteins from your own blood.

What Is nSTRIDE APS?

nSTRIDE APS stands for Autologous Protein Solution — a natural treatment made entirely from your own blood.

It works by concentrating powerful anti-inflammatory proteins, white blood cells, and growth factors into a small injection. These “good proteins” help block the destructive inflammation inside arthritic joints, easing pain and protecting cartilage.

This isn’t a steroid. It’s not a filler. It’s a biologic therapy aimed at changing what’s happening inside the joint — not just masking the symptoms.

Indications for nSTRIDE

nSTRIDE APS is designed for people with mild to moderate osteoarthritis, particularly in the knee — though the science supports use in other joints too.

You may be a good candidate if:

  • You’ve been told you have osteoarthritis but want to delay or avoid surgery
  • Pain and stiffness are interfering with your daily life
  • Other conservative treatments (e.g. physio, medications, hyaluronic acid) haven’t helped enough
  • You prefer a natural, regenerative approach using your own body’s healing signals

Benefits of nSTRIDE Therapy

  • Reduces or eliminates joint pain
  • Improves flexibility and movement
  • Lowers joint inflammation
  • May slow the progression of cartilage damage
  • Single-injection therapy with long-lasting results

Science Behind nSTRIDE APS

In an osteoarthritic knee, inflammatory cytokines (“bad” proteins) outnumber anti-inflammatory cytokines (“good” proteins) causing an imbalance resulting in knee pain and cartilage degeneration. The inflammatory proteins IL-1 and TNFα attack the cartilage. These “bad” proteins must be stopped simultaneously to decrease pain and slow cartilage degeneration.

The nSTRIDE APS output introduces high levels of “good” proteins (IL-1ra, sIL-1R, sTNF-RI, and sTNF RII)10 that overwhelm and block the inflammatory cytokines (bad proteins) IL-1 and TNFα,13^ resulting in decreased pain and slowed cartilage degeneration, unlike traditional therapies.

While balance is being restored to the knee, anabolic growth factors (IGF-1 and TGF-β1) are also introduced for beneficial cartilage health. Therefore, nSTRIDE APS creates an ideal therapy which may reduce pain in the knee joint, improve joint function and slow the destruction of cartilage.9^ This therapy is provided in a non-surgical, single injection in the doctor’s office.

Recovery & Aftercare

When Will I Feel a Difference?

Many patients begin to feel improvement within the first week, with pain relief continuing to build over the following weeks.

In clinical studies, most patients experienced benefits lasting at least 12 months, and some reported improvements up to 3 years after a single injection.

Is nSTRIDE Safe?

Yes. Because the treatment is autologous (made from your own blood), there’s no risk of allergic reaction or rejection. Clinical studies have shown the therapy to be safe and well tolerated.

Possible side effects include mild swelling, bruising or discomfort at the injection site or where the blood was drawn — all typically short-lived.

What Should I Expect After the Injection?

We recommend:
• Reducing activity for about 14 days, especially high-impact movements
• Returning to gentle exercise (or physio) gradually as advised
• Using ice and simple pain relief if needed for any injection site discomfort

Your Sozo clinician will provide personalised aftercare advice to support your recovery and maximise the benefits.

Why Choose Sozo for your Joint Health and nSTRIDE Therapy?

At Sozo, our team of MSK specialists are here to provide:

  • Personalised care from skilled clinicians
  • Advanced in-house technology for preparation and guidance
  • A calm, professional setting where your comfort comes first
  • Honest advice about your options — no pressure, just expertise

Ready to Explore nSTRIDE APS?

We believe joint pain doesn’t have to be permanent — and surgery doesn’t have to be your first step.
If you’re ready to take control of your joint pain with a modern, biological approach, we’re here to guide you through it — the Sozo way.